A 30-year-old female presents with fatigue and gingival bleeding for one week, along with recent skin ecchymoses and oozing blood at injection sites. Lab results: hemoglobin (Hb) 70g/L, white blood cell (WBC) count 3.4×10<sup>9</sup>/L, platelets (PLT) 25×10<sup>9</sup>/L; plasma fibrinogen 1.5g/L. Bone marrow shows hypercellularity with 85% abnormal promyelocytes containing coarse azurophilic granules and abundant Auer rods. The primary cause of bleeding is: