A 48-year-old male with a 5-year history of non-insulin-dependent diabetes mellitus (DM) presents with bilateral lower extremity edema. Physical examination: blood pressure (BP) 150/94 mmHg, urinalysis (UA) shows protein (++++), red blood cells (RBC) 10-15/HP, 24-hour urinary protein quantification 4.0 g, plasma albumin (Alb) 30 g/L, serum cholesterol 6.5 mmol/L, serum creatinine (Cr) 120 μmol/L, urine disc electrophoresis shows high molecular weight proteinuria, and serum HBV markers are positive. Fundus examination is negative. The most likely clinical diagnosis is: