Which of the following is incorrect about pyruvate oxidation and decarboxylation?

AIt occurs with dehydrogenation to form acetyl-CoA
BThe reaction is catalyzed by pyruvate dehydrogenase complex, which is irreversible
CThe co-factors required for the reaction include TPP, FAD, lipoic acid, NAD^+, and CoASH
DAcetyl-CoA generated is further oxidized via the citric acid cycle

Correct answer: A. It occurs with dehydrogenation to form acetyl-CoA

ATP does not have an activating role in pyruvate dehydrogenase complex; it is a product of this reaction.

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