Which of the following is a difference between transcription and DNA replication?

AThe genetic information is stored in the base sequence
BNew strand synthesis follows base pairing rules
CRNA polymerase lacks proofreading function
DSynthesis direction is 5'→3'

Correct answer: C. RNA polymerase lacks proofreading function

Key points: Differences between DNA replication and transcription, properties of RNA polymerase. DNA polymerase has 3'→5' exonuclease activity for self-correction; RNA polymerase lacks this function, hence the error rate in transcription is higher than in replication.

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